Advanced glycation end products: possible link between metabolic syndrome and periodontal diseases.
Identifieur interne : 000270 ( Main/Exploration ); précédent : 000269; suivant : 000271Advanced glycation end products: possible link between metabolic syndrome and periodontal diseases.
Auteurs : D. Pietropaoli [Italie] ; A. Monaco ; R. Del Pinto ; M G Cifone ; G. Marzo ; M. GiannoniSource :
- International journal of immunopathology and pharmacology [ 0394-6320 ]
Descripteurs français
- KwdFr :
- Espèces réactives de l'oxygène (métabolisme), Femelle (MeSH), Humains (MeSH), Maladies parodontales (étiologie), Mâle (MeSH), Produits terminaux de glycation avancée (physiologie), Récepteur spécifique des produits finaux de glycosylation avancée (MeSH), Récepteurs immunologiques (physiologie), Syndrome métabolique X (complications), Syndrome métabolique X (métabolisme).
- MESH :
- métabolisme : Espèces réactives de l'oxygène, Syndrome métabolique X.
- physiologie : Produits terminaux de glycation avancée, Récepteurs immunologiques.
- étiologie : Maladies parodontales.
- Femelle, Humains, Mâle, Récepteur spécifique des produits finaux de glycosylation avancée.
English descriptors
- KwdEn :
- Female (MeSH), Glycation End Products, Advanced (physiology), Humans (MeSH), Male (MeSH), Metabolic Syndrome (complications), Metabolic Syndrome (metabolism), Periodontal Diseases (etiology), Reactive Oxygen Species (metabolism), Receptor for Advanced Glycation End Products (MeSH), Receptors, Immunologic (physiology).
- MESH :
- chemical , metabolism : Reactive Oxygen Species.
- chemical , physiology : Glycation End Products, Advanced, Receptors, Immunologic.
- complications : Metabolic Syndrome.
- etiology : Periodontal Diseases.
- metabolism : Metabolic Syndrome.
- Female, Humans, Male, Receptor for Advanced Glycation End Products.
Abstract
On a planetary scale, Metabolic Syndrome (MetS)is the third cause of inability after malnutrition and nicotinism, even higher than water shortage and sedentariness. In the USA, the prevalence is estimated at over 25 percent of the population; in Italy, it involves approximately 25 percent of men and even 27 percent of women. These are very high figures, corresponding to approximately 14 million affected individuals. The prevalence is alarming and must not be underestimated, particularly in the dental field, where more than one patient out of four sitting in a dentist chair is affected. The etiology of periodontal disease has not yet been clarified, and recently the idea to consider it as a multifactor pathology has been developed. Cofactors such as the formation of free radicals of oxygen (ROS), oxidative stress, lipid peroxidation, and formation of glycation end-products (AGEs) probably play an important role in the onset of periodontal disease. The AGEs are compounds physiologically produced by the cells. However, they accumulate and cause pro-inflammatory conditions, when the cellular clearance fails, or in hyperglycemic and oxidative states. All these conditions can be clinically summarized as Metabolic Syndrome. The purpose of this literature review is to establish a relationship between two pathologies with very high prevalence: Metabolic Syndrome and Periodontal Disorder. The literature seems to have clarified that MetS involves a pro-oxidation status, which induces AGE formation. AGEs play a very important role in the course and severity of periodontal diseases.
DOI: 10.1177/039463201202500102
PubMed: 22507312
Affiliations:
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Del Pinto</name></author><author><name sortKey="Cifone, M G" sort="Cifone, M G" uniqKey="Cifone M" first="M G" last="Cifone">M G Cifone</name></author><author><name sortKey="Marzo, G" sort="Marzo, G" uniqKey="Marzo G" first="G" last="Marzo">G. Marzo</name></author><author><name sortKey="Giannoni, M" sort="Giannoni, M" uniqKey="Giannoni M" first="M" last="Giannoni">M. 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Pietropaoli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Sciences, University of L'Aquila, Faculty of Medicine and Surgery, L'Aguila, Italy. davidepietropaoli@gmail.com</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Sciences, University of L'Aquila, Faculty of Medicine and Surgery, L'Aguila</wicri:regionArea><wicri:noRegion>L'Aguila</wicri:noRegion></affiliation></author><author><name sortKey="Monaco, A" sort="Monaco, A" uniqKey="Monaco A" first="A" last="Monaco">A. Monaco</name></author><author><name sortKey="Del Pinto, R" sort="Del Pinto, R" uniqKey="Del Pinto R" first="R" last="Del Pinto">R. Del Pinto</name></author><author><name sortKey="Cifone, M G" sort="Cifone, M G" uniqKey="Cifone M" first="M G" last="Cifone">M G Cifone</name></author><author><name sortKey="Marzo, G" sort="Marzo, G" uniqKey="Marzo G" first="G" last="Marzo">G. 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In the USA, the prevalence is estimated at over 25 percent of the population; in Italy, it involves approximately 25 percent of men and even 27 percent of women. These are very high figures, corresponding to approximately 14 million affected individuals. The prevalence is alarming and must not be underestimated, particularly in the dental field, where more than one patient out of four sitting in a dentist chair is affected. The etiology of periodontal disease has not yet been clarified, and recently the idea to consider it as a multifactor pathology has been developed. Cofactors such as the formation of free radicals of oxygen (ROS), oxidative stress, lipid peroxidation, and formation of glycation end-products (AGEs) probably play an important role in the onset of periodontal disease. The AGEs are compounds physiologically produced by the cells. However, they accumulate and cause pro-inflammatory conditions, when the cellular clearance fails, or in hyperglycemic and oxidative states. All these conditions can be clinically summarized as Metabolic Syndrome. The purpose of this literature review is to establish a relationship between two pathologies with very high prevalence: Metabolic Syndrome and Periodontal Disorder. The literature seems to have clarified that MetS involves a pro-oxidation status, which induces AGE formation. AGEs play a very important role in the course and severity of periodontal diseases.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22507312</PMID><DateCompleted><Year>2012</Year><Month>05</Month><Day>31</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0394-6320</ISSN><JournalIssue CitedMedium="Print"><Volume>25</Volume><Issue>1</Issue><PubDate><MedlineDate>2012 Jan-Mar</MedlineDate></PubDate></JournalIssue><Title>International journal of immunopathology and pharmacology</Title><ISOAbbreviation>Int J Immunopathol Pharmacol</ISOAbbreviation></Journal><ArticleTitle>Advanced glycation end products: possible link between metabolic syndrome and periodontal diseases.</ArticleTitle><Pagination><MedlinePgn>9-17</MedlinePgn></Pagination><Abstract><AbstractText>On a planetary scale, Metabolic Syndrome (MetS)is the third cause of inability after malnutrition and nicotinism, even higher than water shortage and sedentariness. In the USA, the prevalence is estimated at over 25 percent of the population; in Italy, it involves approximately 25 percent of men and even 27 percent of women. These are very high figures, corresponding to approximately 14 million affected individuals. The prevalence is alarming and must not be underestimated, particularly in the dental field, where more than one patient out of four sitting in a dentist chair is affected. The etiology of periodontal disease has not yet been clarified, and recently the idea to consider it as a multifactor pathology has been developed. Cofactors such as the formation of free radicals of oxygen (ROS), oxidative stress, lipid peroxidation, and formation of glycation end-products (AGEs) probably play an important role in the onset of periodontal disease. The AGEs are compounds physiologically produced by the cells. However, they accumulate and cause pro-inflammatory conditions, when the cellular clearance fails, or in hyperglycemic and oxidative states. All these conditions can be clinically summarized as Metabolic Syndrome. The purpose of this literature review is to establish a relationship between two pathologies with very high prevalence: Metabolic Syndrome and Periodontal Disorder. The literature seems to have clarified that MetS involves a pro-oxidation status, which induces AGE formation. 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Del Pinto</name><name sortKey="Giannoni, M" sort="Giannoni, M" uniqKey="Giannoni M" first="M" last="Giannoni">M. Giannoni</name><name sortKey="Marzo, G" sort="Marzo, G" uniqKey="Marzo G" first="G" last="Marzo">G. Marzo</name><name sortKey="Monaco, A" sort="Monaco, A" uniqKey="Monaco A" first="A" last="Monaco">A. Monaco</name></noCountry><country name="Italie"><noRegion><name sortKey="Pietropaoli, D" sort="Pietropaoli, D" uniqKey="Pietropaoli D" first="D" last="Pietropaoli">D. Pietropaoli</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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